Effect of Strontium Ranelate on Multiple Organ Damage in a Rat Sepsis Model
نویسندگان
چکیده
منابع مشابه
Strontium ranelate treatment improves oxidative damage in osteoporotic rat model.
BACKGROUND Osteoporosis is the most common skeletal disorder and is considered a risk of fracture. Most medication used for the treatment of osteoporosis is antiresorptive; however, strontium ranelate (Sr) therapy in postmenopausal women has shown a double effect on resorption and bone formation. In this study, the effect of Sr on status of the oxidative stress and antioxidant defence system wa...
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Osteoporosis is a disease in which the microarchitecture of bone tissue deteriorates, with consequent loss of bone mass. Strontium ranelate (SrR) is currently used for treatment of the condition. SrR may have a dual effect: anabolic (stimulating pre-osteoblast replication) and anti-catabolic (reducing osteoclastic activity). However, its mechanism of action has not yet been completely elucidate...
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Osteoporosis is a bone disease that afflicts millions of people around the world, and a variety of spinal integrity issues, such as degenerative spinal stenosis and spondylolisthesis, are frequently concomitant with osteoporosis and are sometimes treated with spinal interbody fusion surgery. Previous studies have demonstrated the efficacy of strontium ranelate (SrR) treatment of osteoporosis in...
متن کاملEffect of strontium ranelate on pain behavior in an experimental model of osteoarthritis
Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA ...
متن کاملPolymeric strontium ranelate nonahydrate
The title compound, poly[[μ-aqua-tetra-aqua{μ-5-[bis-(carboxyl-atometh-yl)amino]-3-carboxyl-atomethyl-4-cyano-thio-phene-2-carboxyl-ato}distrontium(II)] tetra-hydrate], [Sr(2)(C(12)H(6)N(2)O(8)S)(H(2)O)(5)]·3.79H(2)O, crystallizes with nine- and eight-coordinated Sr(2+) cations. They are bound to seven of the eight ranelate O atoms and five of the water mol-ecules. The SrO(8) and SrO(9) polyhed...
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ژورنال
عنوان ژورنال: Iranian Red Crescent Medical Journal
سال: 2018
ISSN: 2074-1804,2074-1812
DOI: 10.5812/ircmj.68840